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Lilin Wang

University College London, UK

Magnetic nanoparticles have been widely investigated as a promising nano-medicine agent since last decade. A number of in vitroand in vivo results suggest that the chemo-thermotherapy via multifunctional magnetic nanoparticle has positive effect in cancer treatment, which means the vector carrying both hyperthermia reagent and chemotherapy drugs has potential in boosting the therapeutic effect. Thus, the in vivo biodistribution of the carrier is vital for evaluating the efficiency and translating our result from bench to bedside. Hence in this STSM project, radiopharmaceutical has been used to evaluate the in vivo biodistribution. Both the superparamagnetic nanoparticles and two chemo-drugs: doxorubicin and gemcitabine loaded thermo-sensitive liposome were labeled with radioisotope Y90 . The in vitro stability and quality studies were conducted by using instant thin layer chromatography before going into animal work. The percentage of injected activity per gram of every organ was calculated by comparing the activities with appropriate standards for injection dose. The biodistribution of magnetic nanoparticle in rats and mice model showed the similar results to that of previous published papers, which mainly captured by the liver. The liposome capsulated carriers exhibit higher accumulation manner in liver, spleen and kidney. This implies that the potential high organ specific toxicity of thermoliposome needs to be taken account for the further application. And the further experiments need to be done to acquire significant statistic results.

Poster/Oral presentation(s) /Conference abstract(s) originating from this mission